Choice TV Show: Drama
- Grey's Anatomy - WINNER
- Heroes
- House
- Kyle XY
- Lost
- Hannah Montana - WINNER
- Desperate Housewives
- Entourage
- The Office
- Ugly Betty
- Hugh Laurie - House - WINNER
- Jared Padalecki - Supernatural
- Matthew Fox - Lost
- Milo Ventimiglia - Heroes
- Wentworth Miller - Prison Break
- Emily Deschanel - Bones
- Evangeline Lilly - Lost
- Hayden Panettiere - Heroes - WINNER
- Jennifer Love Hewitt - Ghost Whisperer
- Katherine Heigl - Grey's Anatomy
- Adrian Grenier - Entourage
- Charlie Sheen - Two and a Half Men
- David Spade - Rules of Engagement
- Neil Patrick Harris - How I Met Your Mother
- Steve Carell - The Office - WINNER
- Emma Roberts - Unfabulous
- Miley Cyrus - Hannah Montana - WINNER
- Tia D. Mowry - The Game
- America Ferrera - Ugly Betty
- Eva Longoria - Desperate Housewives
- Donald Faison - Scrubs
- Allison Mack - Smallville - WINNER
- Jorge Garcia - Lost
- Kevin Dillon - Entourage
- Jerry Ferrara - Entourage
- Ugly Betty
- Friday Night Lights
- October Road
- Heroes - WINNER
- South of Nowhere
- America Ferrera - Ugly Betty - WINNER
- Matt Dallas - Kyle XY
- Taylor Kitsch - Friday Night Lights
- Hayden Panettiere - Heroes
- Masi Oka - Heroes
- Michael Rosenbaum (Lex Luther) - Smallville
- Vanessa Williams (Wilhelmina Slater) - Ugly Betty - WINNER
- Zachary Quinto (Sylar) - Heroes
- Michael Emerson (Ben) - Lost
- Robert Knepper (Theodore Bagwell) - Prison Break
