'Grey's Anatomy' Season Five Cast

The season five cast of ABC's hit medical series Grey's Anatomy includes: Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel 'Izzie' Stevens, T.R. Knight as George O'Malley, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey and Brooke Smith as Erica Hahn.

More About Grey's Anatomy

• Synopsis and Other Essential Information
• Spoilers/Episode Guide

Cast Biographies

• Ellen Pompeo
• Patrick Dempsey
• Katherine Heigl
• T.R. Knight
• Sandra Oh