Isaiah Washington as "Dr. Preston Burke," Chandra Wilson as "Miranda Bailey," Sandra Oh as "Cristina Yang," James Pickens, Jr. as "Dr. Richard Webber," Ellen Pompeo as "Meredith Grey" and T.R. Knight as "George O'Malley." (Bottom row) Katherine Heigl as "Isobel 'Izzie' Stevens," Justin Chambers as "Alex Karev" and Patrick Dempsey as "Dr. Derek Shepherd" star on "Grey's Anatomy"