Grey's Anatomy Ep. 4/19/07 - Time After Time

April 19, 2007
"Time After Time"

Izzie struggles with her past and turns to George for comfort.

Cristina, feeling Burke slipping away, decides to fight for her relationship, despite the presence of her former love Dr. Marlowe.

Alex becomes more attached to Jane Doe. Did he not learn anything from the Izzie/Denny ordeal?

Meredith and Derek try to define their relationship.

Guest Starring: Elizabeth Reaser as Jane Doe, Roger Rees as Dr. Colin Marlowe, Dee Wallace as Joan Waring, Brent Jennings as Charles, Suzanne Cryer as Caroline Klein, Tim Hopper as Dustin Klein, Marc Vann as hematologist, Steven W. Bailey as Joe, with Mare Winningham as Susan Grey.