Grey's Anatomy Ep. 4/30/06 - Blues for Sister Someone

Sunday, April 30, 2006
"Blues for Sister Someone"

Chris O'Donnell is back and very much in Meredith's life! Could this be the end of the Derek and Meredith saga? Don't bet on it.

Izzie and George have a fight over the details of his personal life, which he intends to keep personal.

Alex begins an internship with Addison, who takes him to task on a sensitive case.

Burke treats his musical hero.

Guest starring on this episode are: Chris O'Donnell as Finn Dandridge, Sara Ramirez as Callie, Jeffrey Dean Morgan as Denny, Albert Hall as Eugene Foote, Jayne Brook as Gwen Graber and Jean Louisa Kelly as Rose Ward.