Grey's Anatomy Ep. 9/27/07 - A Change is Gonna Come - Season Premiere

September 27, 2007
"A Change is Gonna Come"
Season Premiere

What does a bride do when she is left at the alter? She takes her best friend on her honeymoon! Meredith and Cristina return from "their" honeymoon and Cristina begins her search for Burke.

Meredith, Cristina, Izzie and Alex are now residents who have interns working under them. Among the group is George, who failed his exam and must repeat his internship.

Meredith is in for a big shock when her half-sister Lexie Grey is one of the interns -- will Lexie be the next to capture McDreamy's heart?

Callie, who has been promoted to Chief Resident will have her hands full with a resentful Bailey and her new residents.

Derek seeks the comradery of his fellow doctors when he comes to a realization about the future of his relationship with Meredith.

In addition to Lexie Grey, at least two new interns will be introduced this season.